Lowering the Concentration of Copper (II) Chloride
For future research, the concentration of Copper (II) Chloride will be reduced from 300% to either 200% or 100%. The common characteristic of the unsuccessful cyclizations was the 300% Copper (II) Chloride, which may have led to the disintegration of the isoxazoline. This is meant to protect the isoxazoline once it is produced.
Reducing the Time Interval
To achieve the same effect as the first point, the time interval will be adjusted from 24 hours to 3 hours. This means letting the reaction take place for only 3 hours instead of letting it react overnight. This is to prevent the Copper (II) Chloride from overreacting with the isoxazoline produced.
Increasing the Amount of Metal Mediator
To obtain a higher percentage yield, the amount of metal mediator (Palladium, Lead, or Nickel) will be increased and the amount of oxime reduced.
Refining the Lead (II) Acetate Cyclization
One of the most important topics for future research is the refinement of the Lead (II) Acetate cyclization. This can be done by adjusting the reaction set-up by changing proportions or reactants. An example of this would be to use dichloromethane instead of methanol as a solvent.